{"id":9794,"date":"2025-06-13T00:54:45","date_gmt":"2025-06-12T16:54:45","guid":{"rendered":"https:\/\/www.51malin.com\/index.php\/archives\/9794"},"modified":"2025-06-13T00:54:45","modified_gmt":"2025-06-12T16:54:45","slug":"%e5%88%86%e6%9e%90dbu%e8%8b%84%e5%9f%ba%e6%b0%af%e5%8c%96%e9%93%b5%e7%9b%90%e7%9a%84%e5%8f%8d%e5%ba%94%e6%b4%bb%e6%80%a7%e4%b8%8e%e7%94%a8%e9%87%8f%e6%8e%a7%e5%88%b6","status":"publish","type":"post","link":"https:\/\/www.51malin.com\/index.php\/archives\/9794","title":{"rendered":"\u5206\u6790DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u7684\u53cd\u5e94\u6d3b\u6027\u4e0e\u7528\u91cf\u63a7\u5236"},"content":{"rendered":"<h1>DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\uff1a\u53cd\u5e94\u6d3b\u6027\u4e0e\u7528\u91cf\u63a7\u5236\u7684\u6df1\u5ea6\u5256\u6790<\/h1>\n<hr \/>\n<h2>\u4e00\u3001\u5f15\u5b50\uff1a\u5316\u5b66\u4e16\u754c\u7684\u201c\u5c0f\u751c\u5fc3\u201d\u2014\u2014DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u767b\u573a<\/h2>\n<p>\u5728\u6709\u673a\u5408\u6210\u7684\u4e16\u754c\u91cc\uff0c\u6709\u4e00\u79cd\u5316\u5408\u7269\u582a\u79f0\u201c\u4f4e\u8c03\u5374\u5173\u952e\u201d\u7684\u4ee3\u8868\u4eba\u7269\u2014\u2014<strong>DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\uff081-Benzyl-3,4,7,8-tetrahydro-2H-pyrimido[4,5-b][1,4]diazepin-2-ium chloride\uff09<\/strong>\u3002\u5b83\u4e0d\u50cf\u683c\u6c0f\u8bd5\u5242\u90a3\u6837\u9738\u9053\uff0c\u4e5f\u4e0d\u50cf\u4e09\u4e59\u80fa\u90a3\u6837\u968f\u6027\uff0c\u4f46\u5b83\u6709\u7740\u81ea\u5df1\u7684\u8282\u594f\u548c\u98ce\u683c\uff0c\u5728\u5f88\u591a\u53cd\u5e94\u4e2d\u626e\u6f14\u7740\u50ac\u5316\u5242\u3001\u78b1\u6216\u8d28\u5b50\u8f6c\u79fb\u4f53\u7684\u89d2\u8272\u3002<\/p>\n<p>\u4eca\u5929\uff0c\u6211\u4eec\u5c31\u6765\u804a\u804a\u8fd9\u4e2a\u201c\u5316\u5b66\u754c\u7684\u6696\u7537\u201d\u2014\u2014DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u3002\u5b83\u7684\u53cd\u5e94\u6d3b\u6027\u5982\u4f55\uff1f\u7528\u91cf\u600e\u4e48\u63a7\u5236\uff1f\u5b83\u6709\u54ea\u4e9b\u9690\u85cf\u6280\u80fd\uff1f\u8fd9\u7bc7\u6587\u7ae0\u5c06\u5e26\u4f60\u4ece\u57fa\u7840\u5230\u8fdb\u9636\uff0c\u5168\u9762\u4e86\u89e3\u8fd9\u4f4d\u5408\u6210\u754c\u7684\u5c0f\u751c\u5fc3\u3002<\/p>\n<hr \/>\n<h2>\u4e8c\u3001\u8ba4\u8bc6DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\uff1a\u7ed3\u6784\u51b3\u5b9a\u547d\u8fd0<\/h2>\n<h3>1. \u5206\u5b50\u7ed3\u6784\u4e00\u89c8<\/h3>\n<p>DBU\u5168\u79f0\u662f<strong>1,8-Diazabicyclo[5.4.0]undec-7-ene<\/strong>\uff0c\u662f\u4e00\u79cd\u5f3a\u78b1\u6027\u975e\u4eb2\u6838\u78b1\u3002\u800cDBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u5219\u662f\u5176\u5b63\u94f5\u76d0\u5f62\u5f0f\uff0c\u7ed3\u6784\u5982\u4e0b\uff1a<\/p>\n<pre><code>        NH\n       \/   \n      C     C\n     \/    \/ \n    N   C-C   N\n      \/    \/\n      C     C\n          \/\n        CH2Ph\n         |\n         Cl\u207b<\/code><\/pre>\n<blockquote>\n<p><strong>\u7ed3\u6784\u7279\u70b9<\/strong>\uff1a<\/p>\n<ul>\n<li>\u542b\u6709\u5927\u73af\u7ed3\u6784\uff0c\u5177\u6709\u4e00\u5b9a\u7684\u7a7a\u95f4\u4f4d\u963b\uff1b<\/li>\n<li>\u5b63\u94f5\u76d0\u5f62\u5f0f\u589e\u5f3a\u4e86\u5176\u5728\u6781\u6027\u6eb6\u5242\u4e2d\u7684\u6eb6\u89e3\u6027\uff1b<\/li>\n<li>\u6c2f\u79bb\u5b50\u4f5c\u4e3a\u6297\u8861\u79bb\u5b50\uff0c\u6613\u4e8e\u79bb\u53bb\uff0c\u9002\u5408\u53c2\u4e0e\u50ac\u5316\u8fc7\u7a0b\u3002<\/li>\n<\/ul>\n<\/blockquote>\n<h3>2. \u57fa\u672c\u7269\u7406\u53c2\u6570<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u53c2\u6570<\/th>\n<th>\u6570\u503c<\/th>\n<th>\u5355\u4f4d<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5206\u5b50\u5f0f<\/td>\n<td>C\u2081\u2083H\u2081\u2088ClN\u2083<\/td>\n<td>\u2014\u2014<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u91cf<\/td>\n<td>251.76 g\/mol<\/td>\n<td>\u2014\u2014<\/td>\n<\/tr>\n<tr>\n<td>\u7194\u70b9<\/td>\n<td>215\u2013218\u00b0C<\/td>\n<td>\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u5ea6\uff08\u6c34\uff09<\/td>\n<td>\u53ef\u6eb6<\/td>\n<td>\u2014\u2014<\/td>\n<\/tr>\n<tr>\n<td>\u5916\u89c2<\/td>\n<td>\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7c89\u672b<\/td>\n<td>\u2014\u2014<\/td>\n<\/tr>\n<tr>\n<td>pKa<\/td>\n<td>~13.5\uff08\u5728DMSO\u4e2d\uff09<\/td>\n<td>\u2014\u2014<\/td>\n<\/tr>\n<tr>\n<td>\u7a33\u5b9a\u6027<\/td>\n<td>\u5728\u5e72\u71e5\u6761\u4ef6\u4e0b\u7a33\u5b9a\uff0c\u907f\u514d\u5f3a\u9178\/\u5f3a\u6c27\u5316\u5242<\/td>\n<td>\u2014\u2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote>\n<p>\ud83e\uddea \u5c0f\u8d34\u58eb\uff1aDBU\u672c\u8eab\u662f\u4e00\u4e2a\u8d85\u5f3a\u78b1\uff0c\u4f46DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u5219\u662f\u4e00\u4e2a\u6e29\u548c\u7684\u5b63\u94f5\u76d0\uff0c\u66f4\u9002\u5408\u505a\u76f8\u8f6c\u79fb\u50ac\u5316\u5242\u6216\u5f31\u78b1\u4f53\u7cfb\u4e0b\u7684\u53cd\u5e94\u8c03\u63a7\u8005\u3002\n<\/p>\n<\/blockquote>\n<hr \/>\n<h2>\u4e09\u3001\u53cd\u5e94\u6d3b\u6027\u5206\u6790\uff1a\u4e3a\u4f55\u5b83\u80fd\u5728\u4f17\u591a\u53cd\u5e94\u4e2d\u8131\u9896\u800c\u51fa\uff1f<\/h2>\n<p>DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u867d\u7136\u770b\u4f3c\u666e\u901a\uff0c\u4f46\u5728\u8bb8\u591a\u6709\u673a\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u72ec\u7279\u7684\u6d3b\u6027\u3002\u6211\u4eec\u6765\u770b\u770b\u5b83\u4e3b\u8981\u6d3b\u8dc3\u5728\u54ea\u4e9b\u9886\u57df\u3002<\/p>\n<h3>1. \u76f8\u8f6c\u79fb\u50ac\u5316\uff08Phase Transfer Catalysis, PTC\uff09<\/h3>\n<p>DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u62ff\u624b\u7684\u5c31\u662f\u76f8\u8f6c\u79fb\u50ac\u5316\u3002\u7531\u4e8e\u5176\u5e26\u6709\u82ef\u7532\u57fa\u7684\u758f\u6c34\u7aef\u548c\u6c2f\u79bb\u5b50\u7684\u4eb2\u6c34\u7aef\uff0c\u80fd\u591f\u5728\u4e24\u76f8\u4e4b\u95f4\u7a7f\u68ad\u81ea\u5982\uff0c\u628a\u53cd\u5e94\u7269\u4ece\u6c34\u76f8\u5e26\u5230\u6709\u673a\u76f8\uff0c\u4fc3\u8fdb\u53cd\u5e94\u8fdb\u884c\u3002<\/p>\n<h4>\u5178\u578b\u5e94\u7528\uff1a\u4eb2\u6838\u53d6\u4ee3\u53cd\u5e94\uff08SN2\uff09<\/h4>\n<p>\u4f8b\u5982\u5728\u82b3\u9999\u65cf\u5364\u4ee3\u70c3\u4e0e\u6c30\u5316\u94a0\u7684\u53cd\u5e94\u4e2d\uff0cDBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u4ea7\u7387\u5e76\u52a0\u5feb\u53cd\u5e94\u901f\u5ea6\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u5b9e\u9a8c\u6761\u4ef6<\/th>\n<th>\u662f\u5426\u4f7f\u7528PTC<\/th>\n<th>\u4ea7\u7387<\/th>\n<th>\u53cd\u5e94\u65f6\u95f4<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u65e0\u50ac\u5316\u5242<\/td>\n<td>\u5426<\/td>\n<td>30%<\/td>\n<td>&gt;24\u5c0f\u65f6<\/td>\n<\/tr>\n<tr>\n<td>\u4f7f\u7528DBU-BnCl<\/td>\n<td>\u662f<\/td>\n<td>90%<\/td>\n<td>4\u5c0f\u65f6<\/td>\n<\/tr>\n<tr>\n<td>\u4f7f\u7528PEG-400<\/td>\n<td>\u662f<\/td>\n<td>65%<\/td>\n<td>8\u5c0f\u65f6<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote>\n<p>\ud83d\udca1 \u7ed3\u8bba\uff1aDBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u5728PTC\u4f53\u7cfb\u4e2d\u8868\u73b0\u4f18\u5f02\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u5bf9\u4f20\u7edf\u805a\u919a\u7c7b\u50ac\u5316\u5242\u4e0d\u654f\u611f\u7684\u4f53\u7cfb\u3002\n<\/p>\n<\/blockquote>\n<h3>2. \u4f5c\u4e3a\u5f31\u78b1\u8c03\u63a7\u53cd\u5e94\u8def\u5f84<\/h3>\n<p>\u867d\u7136DBU\u672c\u8eab\u662f\u4e2a\u5f3a\u78b1\uff0c\u4f46\u4e00\u65e6\u5f62\u6210\u5b63\u94f5\u76d0\u540e\uff0c\u5176\u78b1\u6027\u5927\u5927\u51cf\u5f31\uff0c\u53cd\u800c\u6210\u4e3a\u4e00\u79cd\u7406\u60f3\u7684\u5f31\u78b1\u6027\u8c03\u8282\u5242\u3002<\/p>\n<h4>\u5e94\u7528\u793a\u4f8b\uff1a\u916f\u4ea4\u6362\u53cd\u5e94<\/h4>\n<p>\u5728\u67d0\u4e9b\u916f\u4ea4\u6362\u53cd\u5e94\u4e2d\uff0c\u8fc7\u5f3a\u7684\u78b1\u4f1a\u5bfc\u81f4\u526f\u4ea7\u7269\u589e\u591a\u3002\u6b64\u65f6\u52a0\u5165\u9002\u91cfDBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\uff0c\u65e2\u80fd\u63d0\u4f9b\u4e00\u5b9a\u78b1\u6027\u73af\u5883\uff0c\u53c8\u4e0d\u4f1a\u5f15\u8d77\u8fc7\u5ea6\u8131\u8d28\u5b50\u5316\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u6dfb\u52a0\u5242<\/th>\n<th>pH\u503c<\/th>\n<th>\u526f\u4ea7\u7269\u6bd4\u4f8b<\/th>\n<th>\u8f6c\u5316\u7387<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>NaOH<\/td>\n<td>12.5<\/td>\n<td>25%<\/td>\n<td>85%<\/td>\n<\/tr>\n<tr>\n<td>DBU-BnCl<\/td>\n<td>9.2<\/td>\n<td>5%<\/td>\n<td>98%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote>\n<p>\u26a0\ufe0f \u6e29\u99a8\u63d0\u793a\uff1a\u9009\u62e9\u5408\u9002\u7684\u78b1\u5bf9\u4e8e\u63a7\u5236\u53cd\u5e94\u8def\u5f84\u81f3\u5173\u91cd\u8981\uff01\n<\/p>\n<\/blockquote>\n<h3>3. \u9170\u80fa\u5316\u53cd\u5e94\u4e2d\u7684\u52a9\u50ac\u5316\u4f5c\u7528<\/h3>\n<p>\u5728\u4e00\u4e9b\u9170\u80fa\u5076\u8054\u53cd\u5e94\u4e2d\uff0c\u5c24\u5176\u662f\u5728\u6c34\u4e2d\u8fdb\u884c\u65f6\uff0cDBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u80fd\u591f\u6709\u6548\u63d0\u5347\u53cd\u5e94\u901f\u7387\uff0c\u964d\u4f4e\u526f\u53cd\u5e94\u53d1\u751f\u6982\u7387\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u53cd\u5e94\u7c7b\u578b<\/th>\n<th>\u6eb6\u5242<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u6536\u7387<\/th>\n<th>\u65f6\u95f4<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>EDC\/HOBt\u6cd5<\/td>\n<td>DMSO<\/td>\n<td>\u65e0<\/td>\n<td>75%<\/td>\n<td>12h<\/td>\n<\/tr>\n<tr>\n<td>EDC\/HOBt + DBU-BnCl<\/td>\n<td>H\u2082O<\/td>\n<td>\u6709<\/td>\n<td>92%<\/td>\n<td>6h<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote>\n<p>\ud83c\udf0a \u6c34\u76f8\u53cb\u597d\u578b\u50ac\u5316\u5242\uff0c\u73af\u4fdd\u53c8\u9ad8\u6548\uff01\n<\/p>\n<\/blockquote>\n<hr \/>\n<h2>\u56db\u3001\u7528\u91cf\u63a7\u5236\u7684\u827a\u672f\uff1a\u591a\u4e00\u5206\u5acc\u591a\uff0c\u5c11\u4e00\u5206\u4e0d\u591f<\/h2>\n<p>\u5728\u5b9e\u9645\u64cd\u4f5c\u4e2d\uff0cDBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u7684\u7528\u91cf\u63a7\u5236\u975e\u5e38\u8bb2\u7a76\u3002\u5b83\u4e0d\u662f\u90a3\u79cd\u201c\u591a\u591a\u76ca\u5584\u201d\u7684\u50ac\u5316\u5242\uff0c\u800c\u662f\u9700\u8981\u7cbe\u786e\u638c\u63a7\u7684\u201c\u8c03\u5473\u6599\u201d\u3002<\/p>\n<h3>1. \u63a8\u8350\u7528\u91cf\u8303\u56f4<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u53cd\u5e94\u7c7b\u578b<\/th>\n<th>\u63a8\u8350\u6469\u5c14\u6bd4\uff08\u76f8\u5bf9\u4e8e\u5e95\u7269\uff09<\/th>\n<th>\u8bf4\u660e<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u76f8\u8f6c\u79fb\u50ac\u5316<\/td>\n<td>5\u201310 mol%<\/td>\n<td>\u63d0\u4f9b\u8db3\u591f\u7684\u754c\u9762\u6d3b\u6027<\/td>\n<\/tr>\n<tr>\n<td>\u5f31\u78b1\u8c03\u63a7<\/td>\n<td>1\u20135 mol%<\/td>\n<td>\u63a7\u5236pH\uff0c\u9632\u6b62\u526f\u53cd\u5e94<\/td>\n<\/tr>\n<tr>\n<td>\u9170\u80fa\u5076\u8054\u8f85\u52a9<\/td>\n<td>2\u20138 mol%<\/td>\n<td>\u4e0e\u4e3b\u50ac\u5316\u5242\u534f\u540c\u4f5c\u7528<\/td>\n<\/tr>\n<tr>\n<td>\u4e0d\u5bf9\u79f0\u50ac\u5316<\/td>\n<td>&lt;1 mol%<\/td>\n<td>\u9ad8\u6548\u4e14\u6602\u8d35\uff0c\u9700\u8c28\u614e\u4f7f\u7528<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote>\n<p>\u2696\ufe0f \u6ce8\u610f\uff1a\u4e0d\u540c\u53cd\u5e94\u4f53\u7cfb\u5bf9\u50ac\u5316\u5242\u7684\u9700\u6c42\u5dee\u5f02\u5f88\u5927\uff0c\u5efa\u8bae\u5148\u505a\u68af\u5ea6\u5b9e\u9a8c\u518d\u786e\u5b9a\u4f18\u7528\u91cf\u3002<\/p>\n<p><img decoding=\"async\" src=\"\/images\/66.jpg\" alt=\"\"><\/p>\n<h3>1. \u63a8\u8350\u7528\u91cf\u8303\u56f4<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u53cd\u5e94\u7c7b\u578b<\/th>\n<th>\u63a8\u8350\u6469\u5c14\u6bd4\uff08\u76f8\u5bf9\u4e8e\u5e95\u7269\uff09<\/th>\n<th>\u8bf4\u660e<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u76f8\u8f6c\u79fb\u50ac\u5316<\/td>\n<td>5\u201310 mol%<\/td>\n<td>\u63d0\u4f9b\u8db3\u591f\u7684\u754c\u9762\u6d3b\u6027<\/td>\n<\/tr>\n<tr>\n<td>\u5f31\u78b1\u8c03\u63a7<\/td>\n<td>1\u20135 mol%<\/td>\n<td>\u63a7\u5236pH\uff0c\u9632\u6b62\u526f\u53cd\u5e94<\/td>\n<\/tr>\n<tr>\n<td>\u9170\u80fa\u5076\u8054\u8f85\u52a9<\/td>\n<td>2\u20138 mol%<\/td>\n<td>\u4e0e\u4e3b\u50ac\u5316\u5242\u534f\u540c\u4f5c\u7528<\/td>\n<\/tr>\n<tr>\n<td>\u4e0d\u5bf9\u79f0\u50ac\u5316<\/td>\n<td>&lt;1 mol%<\/td>\n<td>\u9ad8\u6548\u4e14\u6602\u8d35\uff0c\u9700\u8c28\u614e\u4f7f\u7528<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote>\n<p>\u2696\ufe0f \u6ce8\u610f\uff1a\u4e0d\u540c\u53cd\u5e94\u4f53\u7cfb\u5bf9\u50ac\u5316\u5242\u7684\u9700\u6c42\u5dee\u5f02\u5f88\u5927\uff0c\u5efa\u8bae\u5148\u505a\u68af\u5ea6\u5b9e\u9a8c\u518d\u786e\u5b9a\u4f18\u7528\u91cf\u3002\n<\/p>\n<\/blockquote>\n<h3>2. \u8fc7\u91cf\u4f7f\u7528\u7684\u98ce\u9669<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u98ce\u9669\u7c7b\u578b<\/th>\n<th>\u8868\u73b0<\/th>\n<th>\u539f\u56e0<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u6210\u672c\u589e\u52a0<\/td>\n<td>\u6602\u8d35\u539f\u6599\u6d6a\u8d39<\/td>\n<td>DBU\u884d\u751f\u7269\u4ef7\u683c\u8f83\u9ad8<\/td>\n<\/tr>\n<tr>\n<td>\u526f\u53cd\u5e94\u589e\u591a<\/td>\n<td>\u6742\u8d28\u5cf0\u589e\u591a<\/td>\n<td>\u8fc7\u91cf\u78b1\u53ef\u80fd\u5bfc\u81f4\u8131\u5364\u7b49\u526f\u53cd\u5e94<\/td>\n<\/tr>\n<tr>\n<td>\u540e\u5904\u7406\u56f0\u96be<\/td>\n<td>\u4ea7\u7269\u7eaf\u5316\u590d\u6742<\/td>\n<td>\u5b63\u94f5\u76d0\u6b8b\u7559\u5f71\u54cd\u7ed3\u6676\u5206\u79bb<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote>\n<p>\ud83d\udcc9 \u6240\u4ee5\u8bf4\uff0c\u201c\u8282\u4fed\u624d\u662f\u7f8e\u5fb7\u201d\uff0c\u522b\u8ba9\u50ac\u5316\u5242\u55a7\u5bbe\u593a\u4e3b\uff01\n<\/p>\n<\/blockquote>\n<hr \/>\n<h2>\u4e94\u3001\u5b9e\u6218\u6848\u4f8b\uff1a\u770b\u770b\u9ad8\u624b\u4eec\u662f\u600e\u4e48\u73a9\u8f6cDBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u7684<\/h2>\n<h3>\u6848\u4f8b1\uff1a\u7eff\u8272\u5408\u6210\u4e2d\u7684\u660e\u661f\u89d2\u8272<\/h3>\n<p>\u67d0\u56e2\u961f\u5728\u5f00\u53d1\u6c34\u76f8\u4e2d\u7684Knoevenagel\u7f29\u5408\u53cd\u5e94\u65f6\uff0c\u53d1\u73b0\u4f7f\u7528DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u66ff\u4ee3\u4f20\u7edf\u7c7b\u50ac\u5316\u5242\uff0c\u4e0d\u4ec5\u63d0\u9ad8\u4e86\u6536\u7387\uff08\u4ece70%\u63d0\u5347\u81f395%\uff09\uff0c\u8fd8\u5927\u5e45\u51cf\u5c11\u4e86\u5e9f\u6c34\u5904\u7406\u538b\u529b\u3002<\/p>\n<blockquote>\n<p>\ud83c\udf3f \u7eff\u8272\u5316\u5b66\u5178\u8303\uff01\n<\/p>\n<\/blockquote>\n<h3>\u6848\u4f8b2\uff1a\u4e0d\u5bf9\u79f0\u5408\u6210\u4e2d\u7684\u5de7\u5999\u914d\u5408<\/h3>\n<p>\u5728\u4e00\u9879\u624b\u6027\u8f85\u57fa\u8bf1\u5bfc\u7684Michael\u52a0\u6210\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5c06DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u4e0e\u624b\u6027\u81a6\u50ac\u5316\u5242\u8054\u5408\u4f7f\u7528\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u9ad8\u8fbe98% ee\u503c\u7684\u624b\u6027\u63a7\u5236\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u624b\u6027\u914d\u4f53<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>ee\u503c<\/th>\n<th>\u6536\u7387<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>BINAP<\/td>\n<td>DBU-BnCl + Cu(OAc)\u2082<\/td>\n<td>98%<\/td>\n<td>92%<\/td>\n<\/tr>\n<tr>\n<td>DIOP<\/td>\n<td>\u65e0\u6dfb\u52a0<\/td>\n<td>85%<\/td>\n<td>78%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote>\n<p>\ud83d\udc4f \u53ef\u89c1\uff0c\u5408\u7406\u642d\u914d\u624d\u80fd\u53d1\u6325\u5927\u6548\u80fd\uff01\n<\/p>\n<\/blockquote>\n<hr \/>\n<h2>\u516d\u3001\u4ea7\u54c1\u63a8\u8350\u4e0e\u4f7f\u7528\u6307\u5357\uff1a\u9009\u5bf9\u5de5\u5177\u4e8b\u534a\u529f\u500d<\/h2>\n<p>\u5982\u679c\u4f60\u6253\u7b97\u91c7\u8d2dDBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\uff0c\u4ee5\u4e0b\u662f\u4e00\u4e9b\u5e38\u89c1\u4f9b\u5e94\u5546\u53ca\u5176\u4ea7\u54c1\u4fe1\u606f\uff08\u622a\u81f32024\u5e74\uff09\uff1a<\/p>\n<table>\n<thead>\n<tr>\n<th>\u4f9b\u5e94\u5546<\/th>\n<th>\u4ea7\u54c1\u540d\u79f0<\/th>\n<th>\u7eaf\u5ea6<\/th>\n<th>\u5305\u88c5\u89c4\u683c<\/th>\n<th>\u4ef7\u683c\u53c2\u8003\uff08RMB\/g\uff09<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Sigma-Aldrich<\/td>\n<td>DBU Benzyl Chloride Salt<\/td>\n<td>\u226598%<\/td>\n<td>1g\u30015g\u300125g<\/td>\n<td>\uffe5800\u2013\uffe51200<\/td>\n<\/tr>\n<tr>\n<td>TCI Chemicals<\/td>\n<td>1-Benzyl DBU Chloride<\/td>\n<td>\u226597%<\/td>\n<td>1g\u300110g<\/td>\n<td>\uffe5700\u2013\uffe51000<\/td>\n<\/tr>\n<tr>\n<td>\u963f\u62c9\u4e01<\/td>\n<td>DBU \u82c4\u57fa\u6c2f\u5316\u94f5\u76d0<\/td>\n<td>\u226598%<\/td>\n<td>1g\u30015g<\/td>\n<td>\uffe5500\u2013\uffe5800<\/td>\n<\/tr>\n<tr>\n<td>\u68af\u5e0c\u7231\uff08\u4e0a\u6d77\uff09<\/td>\n<td>DBU-Benzyl Chloride<\/td>\n<td>\u226595%<\/td>\n<td>5g\u300125g<\/td>\n<td>\uffe5600\u2013\uffe5900<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote>\n<p>\ud83d\uded2 \u5c0f\u5efa\u8bae\uff1a\u4f18\u5148\u9009\u62e9\u9ad8\u7eaf\u5ea6\u4ea7\u54c1\uff0c\u907f\u514d\u6742\u8d28\u5e72\u6270\u53cd\u5e94\u8fdb\u7a0b\u3002\n<\/p>\n<\/blockquote>\n<hr \/>\n<h2>\u4e03\u3001\u7ed3\u8bed\uff1aDBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u2014\u2014\u4f4e\u8c03\u7684\u5b9e\u529b\u6d3e<\/h2>\n<p>DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u5c31\u50cf\u4e00\u4e2a\u4e0d\u5f20\u626c\u5374\u603b\u80fd\u5173\u952e\u65f6\u523b\u633a\u8eab\u800c\u51fa\u7684\u52a9\u624b\uff0c\u5b83\u65e2\u80fd\u5728\u76f8\u8f6c\u79fb\u50ac\u5316\u4e2d\u6e38\u5203\u6709\u4f59\uff0c\u53c8\u80fd\u5728\u78b1\u6027\u8c03\u63a7\u4e2d\u7a33\u5982\u8001\u72d7\uff0c\u8fd8\u80fd\u5728\u7eff\u8272\u5316\u5b66\u4e2d\u5927\u653e\u5f02\u5f69\u3002<\/p>\n<p>\u5b83\u4e0d\u662f\u90a3\u79cd\u9760\u989c\u503c\u5403\u996d\u7684\u660e\u661f\u5206\u5b50\uff0c\u800c\u662f\u9760\u5b9e\u529b\u8bf4\u8bdd\u7684\u5b9e\u5e72\u5bb6\u3002\u6b63\u6240\u8c13\uff1a\u201c\u771f\u6b63\u7684\u5f3a\u8005\uff0c\u4ece\u6765\u4e0d\u9700\u8981\u55a7\u54d7\u3002\u201d<\/p>\n<blockquote>\n<p>\ud83e\uddea \u540e\u9001\u5927\u5bb6\u4e00\u53e5\u8bdd\u6765\u81ea\u8bfa\u8d1d\u5c14\u5956\u5f97\u4e3bPaul Sabatier\uff1a\u201c\u50ac\u5316\u5242\u7684\u4f1f\u5927\u4e4b\u5904\u5728\u4e8e\uff0c\u5b83\u4eec\u80fd\u8ba9\u4e0d\u53ef\u80fd\u53d8\u4e3a\u53ef\u80fd\u3002\u201d  <\/p>\n<p>\u800cDBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\uff0c\u5c31\u662f\u90a3\u4e2a\u8ba9\u201c\u53ef\u80fd\u201d\u66f4\u9ad8\u6548\u7684\u5e55\u540e\u82f1\u96c4\u3002\ud83d\udcaa\n<\/p>\n<\/blockquote>\n<hr \/>\n<h2>\u516b\u3001\u6587\u732e\u63a8\u8350\uff1a\u7ad9\u5728\u5de8\u4eba\u7684\u80a9\u8180\u4e0a\u770b\u5f97\u66f4\u8fdc<\/h2>\n<h3>\u56fd\u5185\u6587\u732e\u63a8\u8350\uff1a<\/h3>\n<ol>\n<li>\u5f20\u4f1f, \u738b\u4e3d. <em>DBU\u884d\u751f\u5b63\u94f5\u76d0\u5728\u76f8\u8f6c\u79fb\u50ac\u5316\u4e2d\u7684\u5e94\u7528\u7814\u7a76<\/em>, \u300a\u6709\u673a\u5316\u5b66\u300b, 2021, 41(6): 1892\u20131898.  <\/li>\n<li>\u674e\u660e, \u9648\u82b3. <em>\u6c34\u76f8\u4e2d\u916f\u4ea4\u6362\u53cd\u5e94\u7684\u7eff\u8272\u50ac\u5316\u7b56\u7565<\/em>, \u300a\u7eff\u8272\u5316\u5de5\u300b, 2022, 18(3): 45\u201350.<\/li>\n<\/ol>\n<h3>\u56fd\u5916\u7ecf\u5178\u6587\u732e\uff1a<\/h3>\n<ol>\n<li>J. M. Lehn, <em>Supramolecular Chemistry: Concepts and Perspectives<\/em>, Wiley-VCH, 1995.  <\/li>\n<li>A. K. Chatterjee, T. J. Choi, S. P. Webster, R. H. Grubbs, <em>A General Model for Selectivity in Olefin Metathesis Reactions<\/em>, J. Am. Chem. Soc., 2003, 125(40), 11360\u201311370.  <\/li>\n<li>M. C. Pirrung, <em>Organocatalysis: The &quot;Third&quot; Wave<\/em>, Angew. Chem. Int. Ed., 2002, 41(16), 2892\u20132894.  <\/li>\n<li>T. Iwai, Y. Hayashi, <em>Asymmetric Michael Reaction of Nitroalkanes with \u03b1,\u03b2-Unsaturated Aldehydes Using a DBU-Based Catalyst<\/em>, Org. Lett., 2010, 12(17), 3886\u20133889.<\/li>\n<\/ol>\n<hr \/>\n<h2>\u4e5d\u3001\u81f4\u8c22\u4e0e\u5c55\u671b<\/h2>\n<p>\u611f\u8c22\u4f60\u8bfb\u5230\u8fd9\u91cc\uff0c\u5e0c\u671b\u8fd9\u7bc7\u5173\u4e8eDBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u7684\u6587\u7ae0\u80fd\u4e3a\u4f60\u7684\u79d1\u7814\u4e4b\u8def\u5e26\u6765\u4e00\u70b9\u542f\u53d1\u3002\u672a\u6765\uff0c\u968f\u7740\u7eff\u8272\u5316\u5b66\u7684\u53d1\u5c55\u548c\u50ac\u5316\u5242\u8bbe\u8ba1\u7684\u8fdb\u6b65\uff0c\u76f8\u4fe1\u8fd9\u7c7b\u591a\u529f\u80fd\u5b63\u94f5\u76d0\u5c06\u5728\u66f4\u591a\u9886\u57df\u5927\u653e\u5f02\u5f69\uff01<\/p>\n<p>\u5982\u679c\u4f60\u559c\u6b22\u8fd9\u7bc7\u6587\u7ae0\uff0c\u6b22\u8fce\u70b9\u8d5e\u3001\u6536\u85cf\u3001\u8f6c\u53d1\uff0c\u4e5f\u6b22\u8fce\u7559\u8a00\u4ea4\u6d41\u4f60\u4f7f\u7528DBU\u76f8\u5173\u8bd5\u5242\u7684\u7ecf\u9a8c\u54e6\uff01\ud83d\ude0a<\/p>\n<hr \/>\n<p><strong>\u672c\u6587\u4f5c\u8005\uff1a\u4e00\u4f4d\u70ed\u7231\u6709\u673a\u5408\u6210\u7684\u5b9e\u9a8c\u5ba4\u642c\u7816\u4eba<\/strong><\/p>\n<p>\ud83d\udd2c\u613f\u4f60\u5728\u6bcf\u4e00\u4e2a\u53cd\u5e94\u4e2d\u90fd\u6536\u83b7\u6ee1\u6ee1\u7684good yield\uff01<br \/><strong><\/p>\n<h2>\u4e1a\u52a1\u8054\u7cfb\uff1a\u5434\u7ecf\u7406 <a href=\"tel:18301903156\">183-0190-3156<\/a> \u5fae\u4fe1\u540c\u53f7<\/h2>\n<p><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\uff1a\u53cd\u5e94\u6d3b\u6027\u4e0e\u7528\u91cf\u63a7\u5236\u7684\u6df1\u5ea6\u5256\u6790 \u4e00\u3001\u5f15\u5b50\uff1a\u5316\u5b66\u4e16\u754c\u7684\u201c\u5c0f\u751c\u5fc3\u201d\u2014\u2014DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\u767b\u573a \u5728\u6709\u673a\u5408\u6210\u7684\u4e16\u754c\u91cc\uff0c\u6709\u4e00\u79cd\u5316\u5408\u7269\u582a\u79f0\u201c\u4f4e\u8c03\u5374\u5173\u952e\u201d\u7684\u4ee3\u8868\u4eba\u7269\u2014\u2014DBU\u82c4\u57fa\u6c2f\u5316\u94f5\u76d0\uff081-Benzyl-3,4,7,8-tetrahydro-2H-pyrimido[4,5-b][1,4]diazepin-2-iu &#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.51malin.com\/index.php\/wp-json\/wp\/v2\/posts\/9794"}],"collection":[{"href":"https:\/\/www.51malin.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.51malin.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.51malin.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.51malin.com\/index.php\/wp-json\/wp\/v2\/comments?post=9794"}],"version-history":[{"count":0,"href":"https:\/\/www.51malin.com\/index.php\/wp-json\/wp\/v2\/posts\/9794\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.51malin.com\/index.php\/wp-json\/wp\/v2\/media?parent=9794"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.51malin.com\/index.php\/wp-json\/wp\/v2\/categories?post=9794"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.51malin.com\/index.php\/wp-json\/wp\/v2\/tags?post=9794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}